Unlocking Metabolic Health Through Your Microbiome

Chapters

• 0:50 Introduction to Gut Microbiome and GLP-1
• 1:23 Gut Flora and GLP-1 Production Mechanics
• 3:10 Understanding Intestinal Permeability
• 5:05 Impact of Probiotics on GLP-1
• 5:37 Dysbiosis and Metabolic Disruption
• 9:18 Improving Gut Health Naturally

Transcript

Speaker 1: 0:27

Hi, how are you? Let's talk about the gut microbiome and metabolic health in our lesson two and the connection between it. How is that working? So we're talking about GLP-1 production, whether it's with medication or the body itself, and what is that doing? It becomes a critical role in regulating our metabolic health. It includes secretions and function of glucagon-like peptides, a hormone essential for blood sugar control and appetite regulation, and insulin sensitivity. Now what does that exactly mean and how do you have a healthy microbiome and how does that enhance the GLP-1 production production In fermentation of dietary fiber.

Speaker 1: 1:13

It's beneficial in the gut biome and main ones that you'll hear about are biphytobacteria and acromansia. So these are fermented prebiotics and you can get this in prebiotic foods like vegetables, legumes, whole grains, and those produce short chain fatty acids, which then will produce butyrate, acetate and propionate and that in turn will help break down different foods and gives you the quality amount of good and bad fiber and body's flora within, and that short chain fatty acids that you're getting in your food will, in turn, stimulate the L cells within the intestine. So I was talking about if you have a good flora there, your GLP-1 production, which produces L cells, will have uptake. So if you don't have the medication, you don't need it and you're eating the right foods and the right amount of prebiotics and and whole foods, you're going to have more uptake and promote more of that, which then will secrete insulin within the body, will slow the gastric emptying which you'd want, which then will control your blood sugar and reduce your hunger. Now we'll talk again more about muscle intake here, but that's just the gist.

Speaker 1: 2:40

So think then you've got your gut and your microbiome and the lining, the barrier, from the mouth all the way down to the. You know, through your end, that lining we want to make sure its integrity is intact. So they call that intestinal permeability and making sure that it's not impermeable, not broken, and it's actually being used. And the junctions are, you know, the things that are supposed to get through are getting in, and not everything. Not the floodgates aren't open, you're just getting what needs to get in. Those locking keys are working and the right nutrients are getting in, but once those things in the permeability or the integrity of that where inflammation is causing that wall to open, it's open and then the floodgates open and then anything can get in, and that's when you have disease and problems. So it controls that. So think of it like when that is intact, you have a balanced microbiome, you're preventing leaky gut, you're reducing inflammation and you have proper GLP-1 secretion.

Speaker 1: 3:44

When you do have a disconnect or a leaky gut or a dysbiosis, you're going to have less JLP one production. So that is also when sometimes you'll hear someone say I've had to uptake my medication. Why do I have to uptake my medication? Well, because you may have a gut health issue. So until you address that sorry, no medication will work. There will be a plateau. So then you have to trick your metabolic system by eating more whole foods, work on cleaning out the inflammation and possibly dysbiosis or integrity of the gut health. When you work on that and fix the chronic inflammation or metabolic dysfunction and reduce the inflammation, you will have more of an uptick of GLP-1. Your medications, if needed, will be there and it'll improve your insulin sensitivity. So that's why it comes down to really understanding and optimizing your body.

Speaker 1: 4:42

Now, how does the impact of probiotics on GLP-1s? Now, this is because, when the studies have shown that lactobacillus and bifidobacterium increases GLP-1 secretion, yes, it leads to improving glucose metabolism. Also, for weight regulation, there's acromansia. That's a big one now and that has helped to reduce and help with weight regulation. Now, how does this dysbiosis um disrupt the GLP-1.

Speaker 1: 5:14

I briefly had stated that in your body when you have that disruption or irregular good and bad microbiotic um uh microflora within the body it will cause it's because of poor diet. You're just eating processed foods, nothing whole, no water, and it's just sugar and junk. You're having antibiotic overuse and chronic stress and lack of sleep. When you put all those things together, you know that'll be a factor right. So think about that as an as important. So when you reduce short chain fatty acid production which means that you're not, you're not eating the whole foods you decrease your GLP-1 production. So naturally your body is not able to do that.

Speaker 1: 5:59

There are some individuals that genetically they have low GLP-1 and in turn they have to really be big on what they put into their body because they're going to go and be more obese than other individuals and that means they're with obesity but they will have that issue of not being able to control their insulin. So there'll be other health issues that may come up. It's not as common but most individuals, due to this the food intake and things that are in our bodies we will have problems. So that's why the gut permeability and leaky gut is. You know it's still important to understand and that the the irregularity of flora will cause inflammatory response and go into the bloodstream. The inflammation can cause insulin resistance, obesity and metabolic problems.

Speaker 1: 6:47

Now, when you have lower acromansia or bifactobacteria levels, which is a probiotics, those are key players in helping with the gut and also helping with regulation of your weight control. Some individuals are just prone to not having as much of it, so they need it into their diet and their individuals. Um, you'll see that when they have less GLP, one or their other hormones start to get dysregulated, whether it's insulin, their leptin, their ghrelin and they're going to start to increase their cravings and more weight gain. In addition, we haven't even talked about exercise in this occasion, but you know the amount of muscle that's needed to kind of bring up the uptick and getting rid of the or regulating the insulin and the glucose within the body. So elevated from firmacutin or bactrocytes I'm saying it a little off, but it's bacteriodites or firmacutes.

Speaker 1: 7:47

These are probiotics that are commonly seen in patients. They're very high in patients that are with obesity and that means their ratio is higher because they're absorbing they're increased volume of calories, processed food, they're storing so much more fat and they're more insulin resistant. So I will see an uptick in this if I did a stool testing and I would see that in the persons and they're not showing enough fatty acids. And this can be regulated, and not only with the medications, but a lot of the nutrition and what they put into their body and it can be improved. But you know, until you understand how important gut health is, you know I can't sit there and tell you that. You know these medications are the only source or if you do it naturally, you're just going to magically get the um, get situated. No, you have to do a little bit of both.

Speaker 1: 8:45

Um now, how do you increase your gut bacteria so that your uptick is higher in the GLP-1 range, so your hormones are better, so that you can have better um insulin regulating? You know insulin regulation optimization. You increase this by having prebiotic fiber, eating things like garlic. Eating things like leeks, asparagus, bananas, flaxseed oats, legumes these things that are beneficial for stimulating not only GLP-1, but just the body's natural movement. Consume fermented foods as long as it's not um causing you in a histamine response.

Speaker 1: 9:21

Probiotic foods. Eat yogurt, kefir, sauerkraut, kimchi um kombucha, as long as you're not high inflammatory allergy um or throat issues Um you'll know. If you're on a low FODMAP diet you might need to have that reduced um reduced foods and processed sugars um. Supplements for probiotics are um lactobacillus bacterium um gut health and metabolic function. Um manage your sleep and stress. You know between like seven to nine hours of sleep. Try to get into that. Quality, quality sleep and exercise is so paramount. I mean this is in a range of things that I will talk about, but in general um, when you um are more insulin resistant because you're you're moving more you're able to do and have more circulation, not to mention strength training um and at least some sort of muscle work to be done. So the main things there that I really want you to understand is that our body can be regulated when it's impacted by the gut flora and when you work on your integrity of the gut lining by eating the right foods and giving it the right nutrients.